AIRE Antibody
Product Specifications
Background
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) .
NCBI Gene ID
326
Swiss Prot
O43918
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human AIRE (NP_000374.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology
Purification
Affinity purification
Positive Control
Raji
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-413
Calculated Molecular Weight
Observed: 50kDa
Fragment
IgG
Symbol
AIRE
Positive Control 2
BxPC-3
Positive Control 3
HepG2
Positive Control 4
Mouse thymus
Positive Control 5
Rat thymus
NCBI Official Name
Autoimmune regulator
NCBI Organism
Homo sapiens
Other Product Names
AIRE, APS1, APSI, PGA1, AIRE1, APECED
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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