HLA-DPB1 Antibody
Product Specifications
Background
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
NCBI Gene ID
3115
Swiss Prot
P04440
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human HLA-DPB1 (NP_002112.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Affinity purification
Positive Control
U-937
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-381
Calculated Molecular Weight
Observed: 27-29kDa
Fragment
IgG
Symbol
HLA-DPB1
Positive Control 2
THP-1
Positive Control 3
Mouse spleen
Positive Control 4
Mouse thymus
NCBI Official Name
HLA class II histocompatibility antigen, DP beta 1 chain
NCBI Organism
Homo sapiens
Other Product Names
HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP (W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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