HLA-DPB1 Antibody

Product Specifications

Background

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

NCBI Gene ID

3115

Swiss Prot

P04440

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human HLA-DPB1 (NP_002112.3) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

Affinity purification

Positive Control

U-937

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 27-29kDa

Fragment

IgG

Symbol

HLA-DPB1

Positive Control 2

THP-1

Positive Control 3

Mouse spleen

Positive Control 4

Mouse thymus

NCBI Official Name

HLA class II histocompatibility antigen, DP beta 1 chain

NCBI Organism

Homo sapiens

Other Product Names

HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP (W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B