BEST1 Antibody
Product Specifications
Background
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
NCBI Gene ID
7439
Swiss Prot
O76090
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 376-585 of human BEST1 (NP_004174.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
Affinity purification
Positive Control
Mouse liver
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 68kDa
Fragment
IgG
Symbol
BEST1
Positive Control 2
Mouse lung
NCBI Official Name
Bestrophin 1
NCBI Organism
Homo sapiens
Other Product Names
ARB, BEST, BMD, Best1V1Delta2, RP5TU15B, VMD2, bestrophin-1, Best disease, vitelliform macular dystrophy protein 2
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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