PLOD2 Antibody
Product Specifications
Background
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
5352
Swiss Prot
O00469
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 470-650 of human PLOD2 (NP_891988.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-341
Fragment
IgG
Applications Notes
IF: 1:50 - 1:100
Symbol
PLOD2
NCBI Official Name
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
NCBI Organism
Homo sapiens
Other Product Names
BRKS2, LH2, TLH, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, lysine hydroxylase 2, lysyl hydroxlase 2, lysyl hydroxylase 2, procollagen-lysine 5-dioxygenase, telopeptide lysyl hydroxylase
Tested Applications
IF
Physical Properties
Liquid
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