PNP Antibody
Product Specifications
Background
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
NCBI Gene ID
4860
Swiss Prot
P00491
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human PNP (NP_000261.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity purification
Positive Control
NCI-H460
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 32kDa
Fragment
IgG
Symbol
PNP
Positive Control 2
Mouse liver
NCBI Official Name
Purine nucleoside phosphorylase
NCBI Organism
Homo sapiens
Other Product Names
NP, MGC117396, MGC125915, MGC125916, PNP, PRO1837, PUNP, NP
Tested Applications
WB, IF
Physical Properties
Liquid
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