AGA Antibody

Product Specifications

Background

This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing.

NCBI Gene ID

175

Swiss Prot

P20933

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 24-346 of human AGA (NP_000018.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

SW620

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 18kDa

Fragment

IgG

Symbol

AGA

Positive Control 2

THP-1

Positive Control 3

HepG2

Positive Control 4

Mouse liver

Positive Control 5

Mouse pancreas

NCBI Official Name

Aspartylglucosaminidase

NCBI Organism

Homo sapiens

Other Product Names

AGU, ASRG, GA, N (4) - (beta-N-acetylglucosaminyl) -L-asparaginase, N4- (N-acetyl-beta-glucosaminyl) -L-asparagine amidase, aspartylglucosylamine deaspartylase, glycosylasparaginase