RIN2 Antibody
Product Specifications
Background
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
54453
Swiss Prot
Q8WYP3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-208
Calculated Molecular Weight
Observed: 120kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
RIN2
Positive Control 2
A-549
Positive Control 3
HeLa
Positive Control 4
HepG2
Positive Control 5
Mouse heart
Positive Control 6
Mouse kidney
NCBI Official Name
Ras and Rab interactor 2
NCBI Organism
Homo sapiens
Other Product Names
MACS, RASSF4, ras and Rab interactor 2, RAB5 interacting protein 2, RAS association (RalGDS/AF-6) domain containing protein JC265, RAS association domain family 4, RAS inhibitor JC265, RAS interaction/interference protein 2
Tested Applications
WB
Physical Properties
Liquid
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