GCSH Antibody
Product Specifications
Background
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase) . The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH) . Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.
NCBI Gene ID
2653
Swiss Prot
P23434
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human GCSH (NP_004474.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
LO2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=15-155
Calculated Molecular Weight
Observed: 19kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
GCSH
Positive Control 2
293T
Positive Control 3
HeLa
Positive Control 4
Mouse kidney
Positive Control 5
Rat liver
NCBI Official Name
Glycine cleavage system H protein, mitochondrial
NCBI Organism
Homo sapiens
Other Product Names
Glycine cleavage system H protein, mitochondrial, Lipoic acid-containing protein, GCSH
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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