CRY1 Antibody
Product Specifications
Background
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.
NCBI Gene ID
1407
Swiss Prot
Q16526
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human CRY1 (NP_004066.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse testis
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CRY1
Positive Control 2
Mouse eye
Positive Control 3
Rat testis
Positive Control 4
SW480
NCBI Official Name
Cryptochrome circadian clock 1
NCBI Organism
Homo sapiens
Other Product Names
CRY1, Chryptochrome 1, Cryptochrome-1, Photolyase homolog 1, PHLL1
Tested Applications
WB
Physical Properties
Liquid
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