FBL Antibody
Product Specifications
Background
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
NCBI Gene ID
2091
Swiss Prot
P22087
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-321 of human FBL (NP_001427.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 37kDa
Fragment
IgG
Symbol
FBL
Positive Control 2
A375
Positive Control 3
U-2OS
Positive Control 4
COS-1
Positive Control 5
COS-7
Positive Control 6
PC-12
NCBI Official Name
Fibrillarin
NCBI Organism
Homo sapiens
Other Product Names
FBL, FIB, FLRN, RNU3IP1
Tested Applications
WB, IHC, IF, IP
Physical Properties
Liquid
Curated Selection
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