PRKAB2 Antibody
Product Specifications
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
NCBI Gene ID
5565
Swiss Prot
O43741
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human PRKAB2 (NP_005390.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy, Cancer, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=14-931
Calculated Molecular Weight
Observed: 35kDa
Fragment
IgG
Symbol
PRKAB2
Positive Control 2
Mouse heart
Positive Control 3
Mouse brain
Positive Control 4
Rat brain
NCBI Official Name
Protein kinase AMP-activated non-catalytic subunit beta 2
NCBI Organism
Homo sapiens
Other Product Names
5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase, beta-2 subunit, AMP-activated protein kinase beta 2 non-catalytic subunit, AMPK beta 2, AMPK beta-2 chain, AMPK subunit beta-2, protein kinase, AMP-activated, beta 2 non-catalytic subunit
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
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