GDF5 Antibody
Product Specifications
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis.
NCBI Gene ID
8200
Swiss Prot
P43026
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human GDF5 (NP_000548.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
Mouse heart
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 45kDa
Fragment
IgG
Symbol
GDF5
Positive Control 2
Rat heart
NCBI Official Name
Growth differentiation factor 5
NCBI Organism
Homo sapiens
Other Product Names
GDF5, CDMP-1, CDMP1, GDF-5, LAP4, Radotermin, OS5, BMP14, SYNS2
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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