NDUFS2 Antibody, KO Validated

Product Specifications

Background

The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) . Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

4720

Swiss Prot

O75306

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 204-463 of human NDUFS2 (NP_004541.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

LO2

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 49kDa

Fragment

IgG

Symbol

NDUFS2

Positive Control 2

HeLa

Positive Control 3

293T

Positive Control 4

Mouse brain

Positive Control 5

Mouse kidney

Positive Control 6

Mouse spleen

NCBI Official Name

NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)

NCBI Organism

Homo sapiens

Other Product Names

NDUFS2, NADH-ubiqui oxidoreductase NDUFS2 subunit, NADH dehydrogenase (ubiqui) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase), complex 1, mitochondrial respiratory chain, 49-KD subunit, CI-49