CLPS Antibody
Product Specifications
Background
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1208
Swiss Prot
P04118
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human CLPS (NP_001823.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse pancreas
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 12kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CLPS
Positive Control 2
Rat pancreas
NCBI Official Name
Colipase
NCBI Organism
Homo sapiens
Other Product Names
Colipase, colipase, pancreatic, pancreatic colipase preproprotein
Tested Applications
WB
Physical Properties
Liquid
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