IGF1R Antibody
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
NCBI Gene ID
3480
Swiss Prot
P08069
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human IGF1R
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse kidney
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 100kDa
Fragment
IgG
Symbol
IGF1R
Positive Control 2
Mouse lung
Positive Control 3
Mouse testis
NCBI Official Name
Insulin-like growth factor 1 receptor
NCBI Organism
Homo sapiens
Other Product Names
IGF1R, CD221 antigen, CD221, IGF1 Receptor, IGFR, IGF-I receptor, Soluble IGF1R variant 1, Soluble IGF1R variant 2, Type 1 IGF receptor, IGFIR, JTK13
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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