TOP1 Antibody
Product Specifications
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
NCBI Gene ID
7150
Swiss Prot
P11387
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TOP1 (NP_003277.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 120kDa
Fragment
IgG
Symbol
TOP1
Positive Control 2
SKOV3
Positive Control 3
SW480
Positive Control 4
Jurkat
Positive Control 5
HeLa
Positive Control 6
Mouse spleen
NCBI Official Name
DNA topoisomerase I
NCBI Organism
Homo sapiens
Other Product Names
TOPI, DNA topoisomerase 1, Scl-70 antigen, topoisomerase (DNA) I, type I DNA topoisomerase
Tested Applications
WB, IHC, IP
Physical Properties
Liquid
Curated Selection
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