TIA1 Antibody
Product Specifications
Background
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
NCBI Gene ID
7072
Swiss Prot
P31483
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human TIA1 (NP_071505.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Immunology
Purification
Affinity purification
Positive Control
BT-474
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 43-50kDa
Fragment
IgG
Symbol
TIA1
Positive Control 2
Raji
Positive Control 3
Mouse brain
Positive Control 4
Mouse spleen
NCBI Official Name
TIA1 cytotoxic granule-associated RNA binding protein
NCBI Organism
Homo sapiens
Other Product Names
TIA1, WDM, TIA-1
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
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