ALAD Antibody
Product Specifications
Background
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins) . ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
210
Swiss Prot
P13716
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human ALAD (NP_000022.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Positive Control
HL-60
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 36kDa
Fragment
IgG
Symbol
ALAD
Positive Control 2
Mouse liver
Positive Control 3
Mouse kidney
NCBI Official Name
Aminolevulinate dehydratase
NCBI Organism
Homo sapiens
Other Product Names
ALAD, ALADH, MGC5057, PBGS
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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