SPTA1 Antibody

Product Specifications

Background

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.

NCBI Gene ID

6708

Swiss Prot

P02549

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human SPTA1 (NP_003117.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

239T

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 300kDa

Fragment

IgG

Symbol

SPTA1

Positive Control 2

LO2

Positive Control 3

A-549

Positive Control 4

Mouse kidney

Positive Control 5

Mouse liver

Positive Control 6

Mouse lung

NCBI Official Name

Spectrin alpha, erythrocytic 1

NCBI Organism

Homo sapiens

Other Product Names

EL2, HPP, HS3, SPH3, SPTA, spectrin alpha chain, erythrocytic 1, alpha-I spectrin, elliptocytosis 2, erythroid alpha-spectrin, spectrin alpha chain, erythrocyte