PKLR Antibody
Product Specifications
Background
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) . Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
5313
Swiss Prot
P30613
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 446-556 of human PKLR (NP_000289.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 62kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
PKLR
Positive Control 2
HT-29
Positive Control 3
Mouse kidney
Positive Control 4
Mouse liver
Positive Control 5
Rat kidney
NCBI Official Name
Pyruvate kinase, liver and RBC
NCBI Organism
Homo sapiens
Other Product Names
PKLR, PK1, PKL, RPK, PKR, PKRL
Tested Applications
WB
Physical Properties
Liquid
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