ALDH18A1 Antibody
Product Specifications
Background
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
NCBI Gene ID
5832
Swiss Prot
P54886
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
U-87MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=14-332
Calculated Molecular Weight
Observed: 87kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
ALDH18A1
Positive Control 2
Mouse testis
Positive Control 3
Rat brain
NCBI Official Name
Aldehyde dehydrogenase 18 family, member A1
NCBI Organism
Homo sapiens
Other Product Names
ALDH18A1, pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase), PYCS, P5CS, MGC117316, GSAS, delta1-pyrroline-5-carboxlate synthetase, aldehyde dehydrogenase 18A1, aldehyde dehydrogenase 18 family, member A1
Tested Applications
WB
Physical Properties
Liquid
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