HLA-DOB Antibody
Product Specifications
Background
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
NCBI Gene ID
3112
Swiss Prot
P13765
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 27-224 of human HLA-DOB (NP_002111.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Affinity purification
Positive Control
B cells
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 31kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:1000
Symbol
HLA-DOB
Positive Control 2
Mouse kidney
Positive Control 3
Mouse spleen
Positive Control 4
Rat liver
NCBI Official Name
Major histocompatibility complex, class II, DO beta
NCBI Organism
Homo sapiens
Other Product Names
DOB, HLA_DOB, HLA class II histocompatibility antigen, DO beta chain, MHC class II antigen DOB
Tested Applications
WB
Physical Properties
Liquid
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