PKLR Antibody
Product Specifications
Background
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) . Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
5313
Swiss Prot
P30613
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 446-556 of human PKLR (NP_000289.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
BxPC-3
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 62kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
PKLR
Positive Control 2
HepG2
Positive Control 3
293T
Positive Control 4
Mouse kidney
Positive Control 5
Mouse liver
Positive Control 6
Mouse heart
NCBI Official Name
Pyruvate kinase, liver and RBC
NCBI Organism
Homo sapiens
Other Product Names
PKLR, PK1, PKL, RPK, PKR, PKRL
Tested Applications
WB
Physical Properties
Liquid
Frequently Asked Questions
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