RASSF1 Antibody
Product Specifications
Background
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
NCBI Gene ID
11186
Swiss Prot
Q9NS23
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 101-340 of human RASSF1 (NP_009113.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 39kDa
Fragment
IgG
Symbol
RASSF1
Positive Control 2
HepG2
Positive Control 3
293T
Positive Control 4
SW480
NCBI Official Name
Ras association domain-containing protein 1
NCBI Organism
Homo sapiens
Other Product Names
Ras association domain-containing protein 1, RASSF1 {ECO:0000312|EMBL:AAF351282}
Tested Applications
WB, IF
Physical Properties
Liquid
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