AKT1 Antibody
Product Specifications
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
NCBI Gene ID
207
Swiss Prot
P31749
Host
Rabbit
Reactivity
Human, Mouse, Rat, Zebrafish
Immunogen
Recombinant protein of human AKT1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=14-185
Calculated Molecular Weight
Observed: 56kDa
Fragment
IgG
Symbol
AKT1
NCBI Official Name
V-akt murine thymoma viral oncogene homolog 1
NCBI Organism
Homo sapiens
Other Product Names
Akt1 Antibody: AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA, Protein kinase B
Tested Applications
WB, IP, Flow
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
