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CRKL Antibody, KO Validated

Product Specifications

Background

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

NCBI Gene ID

1399

Swiss Prot

P46109

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Cancer, Immunology, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

LO2

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=14-122

Calculated Molecular Weight

Observed: 37kDa

Fragment

IgG

Symbol

CRKL

Positive Control 2

Jurkat

Positive Control 3

SKOV3

Positive Control 4

Mouse brain

Positive Control 5

Rat heart

NCBI Official Name

V-crk avian sarcoma virus CT10 oncogene homolog-like

NCBI Organism

Homo sapiens

Other Product Names

CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian) -like, v-crk avian sarcoma virus CT10 oncogene homolog-like

Tested Applications

WB, IF

Physical Properties

Liquid

Curated Selection

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