OTUB1 Antibody

Product Specifications

Background

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

55611

Swiss Prot

Q96FW1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OTUB1 (NP_060140.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 37kDa

Fragment

IgG

Symbol

OTUB1

Positive Control 2

A375

Positive Control 3

HT-29

Positive Control 4

293T

Positive Control 5

Mouse brain

Positive Control 6

Mouse heart

NCBI Official Name

OTU deubiquitinase, ubiquitin aldehyde binding 1

NCBI Organism

Homo sapiens

Other Product Names

OTUB1, OTU domain, ubiquitin aldehyde binding 1, FLJ20113, FLJ40710, HSPC263, MGC111158, MGC4584, OTB1, OTU1, OTU-domain Ubal-binding 1, otubain 1, ubiquitin-specific protease otubain 1