SLC6A5 Antibody
Product Specifications
Background
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
9152
Swiss Prot
Q9Y345
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SLC6A5 (NP_004202.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity purification
Positive Control
SH-SY5Y
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 60kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
SLC6A5
Positive Control 2
U-937
Positive Control 3
U-87MG
Positive Control 4
U-251MG
Positive Control 5
Mouse brain
Positive Control 6
Mouse liver
NCBI Official Name
Solute carrier family 6 member 5
NCBI Organism
Homo sapiens
Other Product Names
GLYT-2, GLYT2, HKPX3, NET1, sodium- and chloride-dependent glycine transporter 2, solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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