IKB alpha Antibody, KO Validated
Product Specifications
Background
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
NCBI Gene ID
4792
Swiss Prot
P25963
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IKB alpha (NP_065390.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Innate Immunity, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
MCF-7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 36kDa
Fragment
IgG
Symbol
NFKBIA
Positive Control 2
DU145
Positive Control 3
THP-1
Positive Control 4
A-549
Positive Control 5
Mouse spleen
Positive Control 6
Mouse thymus
NCBI Official Name
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NCBI Organism
Homo sapiens
Other Product Names
NFKBIA, IKBA, MAD-3, NFKBI
Tested Applications
WB, IP
Physical Properties
Liquid
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