ROCK1 Antibody [H5E4]
Product Specifications
Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
NCBI Gene ID
6093
Swiss Prot
Q13464
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human ROCK1
Clonality
Monoclonal
Clone
[H5E4]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
A-431
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 158kDa
Fragment
IgG
Symbol
ROCK1
Positive Control 2
NIH/3T3
NCBI Official Name
Rho-associated, coiled-coil containing protein kinase 1
NCBI Organism
Homo sapiens
Other Product Names
ROCK1 Antibody: ROCK-I, P160ROCK, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, ROCK-I
Tested Applications
WB, IHC, IF, IP
Physical Properties
Liquid
Curated Selection
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