IRF3 Antibody, KO Validated
Product Specifications
Background
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
NCBI Gene ID
3661
Swiss Prot
Q14653
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human IRF3 (NP_001184051.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Chemokines & Cytokines, Immunology, Innate Immunity, Transcription, Inflammasomes
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 56kDa
Fragment
IgG
Symbol
IRF3
Positive Control 2
HeLa
Positive Control 3
Jurkat
Positive Control 4
HepG2
NCBI Official Name
Interferon regulatory factor 3
NCBI Organism
Homo sapiens
Other Product Names
IRF3 Antibody: Interferon regulatory factor 3, IRF-3
Tested Applications
WB, IHC, ChIP
Physical Properties
Liquid
Frequently Asked Questions
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