ATP2A2 / SERCA2 Antibody

Product Specifications

Background

This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI Gene ID

488

Swiss Prot

P16615

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 111-253 of human ATP2A2 / SERCA2 (NP_733765.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

A-549

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 115kDa

Fragment

IgG

Symbol

ATP2A2

Positive Control 2

THP-1

Positive Control 3

PC-3

Positive Control 4

MCF7

Positive Control 5

A673

Positive Control 6

HeLa

NCBI Official Name

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

NCBI Organism

Homo sapiens

Other Product Names

ATP2A2, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, ATP2B, DAR, DD, DKFZp686P0211, FLJ20293, FLJ38063, MGC45367, SERCA2, ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2, SR Ca (2+) -ATPase 2, calcium pump 2, calcium-transporting ATPase s