SDHB Antibody
Product Specifications
Background
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
NCBI Gene ID
6390
Swiss Prot
P21912
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 32kDa
Fragment
IgG
Symbol
SDHB
Positive Control 2
HeLa
Positive Control 3
U-87MG
Positive Control 4
Mouse brain
Positive Control 5
Mouse liver
Positive Control 6
Mouse kidney
NCBI Official Name
Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
NCBI Organism
Homo sapiens
Other Product Names
SDHB, IP, PGL4, SDH, SDH1, SDHIP, CWS2, SDH2
Tested Applications
WB, IHC
Physical Properties
Liquid
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