MCM3 Antibody
Product Specifications
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
4172
Swiss Prot
P25205
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human MCM3 (NP_002379.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=13-753
Calculated Molecular Weight
Observed: 105kDa
Fragment
IgG
Symbol
MCM3
Positive Control 2
293T
Positive Control 3
PC-12
Positive Control 4
NIH/3T3
Positive Control 5
COS-1
Positive Control 6
COS-7
NCBI Official Name
Minichromosome maintenance complex component 3
NCBI Organism
Homo sapiens
Other Product Names
MCM3, HCC5, MGC1157, P1-MCM3, P1.h, RLFB
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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