YWHAE Antibody
Product Specifications
Background
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
NCBI Gene ID
7531
Swiss Prot
P62258
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human YWHAE (NP_006752.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 29kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
YWHAE
Positive Control 2
HepG2
Positive Control 3
NIH/3T3
Positive Control 4
SH-SY5Y
Positive Control 5
Mouse kidney
Positive Control 6
Rat liver
NCBI Official Name
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
NCBI Organism
Homo sapiens
Other Product Names
YWHAE, 14-3-3E, 14-3-3 epsilon, 14-3-3 protein epsilon, MDCR, MDS, KCIP-1
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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