Radafaxine (hydrochloride)

Radafaxine hydrochloride (GW-353162A) is a DAT (dopamine transporter) and NET (norepinephrine transporter) transporters inhibitor, and nAChR family modulator. Radafaxine hydrochloride (GW-353162A) is a potent metabolite of bupropion and selective for inhibiting the reuptake of norepinephrine over dopamine[1][2][3].

Product Specifications

CAS Number

[106083-71-0]

Product Name Alternative

(S, S) -Hydroxybupropion (hydrochloride) ; GW-353162A; BW-306U

UNSPSC

12352005

Hazard Statement

H319, H402

Target

Monoamine Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Radafaxine-hydrochloride.html

Purity

99.01

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O[C@]1(C2=CC=CC(Cl)=C2)[C@H](C)NC(C)(C)CO1.[H]Cl

Molecular Formula

C13H19Cl2NO2

Molecular Weight

292.21

Precautions

H319, H402

References & Citations

[1]Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19 (3) :163-70.|[2]Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474 (1) :85-93.|[3]Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57 (6) :640-6.