NUDT5 Antibody

Product Specifications

Background

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors.

NCBI Gene ID

11164

Swiss Prot

Q9UKK9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-219 of human NUDT5 (NP_054861.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 36kDa

Fragment

IgG

Applications Notes

WB: 1:1000 - 1:2000

Symbol

NUDT5

Positive Control 2

LO2

Positive Control 3

DU145

Positive Control 4

HT-1080

Positive Control 5

Mouse liver

Positive Control 6

Mouse kidney

NCBI Official Name

Nudix hydrolase 5

NCBI Organism

Homo sapiens

Other Product Names

YSA1, YSA1H, YSAH1, hNUDT5, ADP-sugar pyrophosphatase, 8-oxo-dGDP phosphatase, nuclear ATP-synthesis protein NUDIX5, nudix (nucleoside diphosphate linked moiety X) -type motif 5