DDR1 Antibody

Product Specifications

Background

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI Gene ID

780

Swiss Prot

Q08345

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 290-420 of human DDR1 (NP_054700.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

293T

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 125kDa

Fragment

IgG

Applications Notes

WB: 1:1000 - 1:2000

Symbol

DDR1

Positive Control 2

SW480

NCBI Official Name

Discoidin domain receptor tyrosine kinase 1

NCBI Organism

Homo sapiens

Other Product Names

DDR1, Cell adhesion kinase, CD167, CD167a antigen, EDDR1, ENTRK4, Mammary carcinoma kinase 10, MCK10, NEP, PTK3, PTK3A, RTK6, Tyrosine-protein kinase CAK, CAK, DDR, Discoidin domain receptor 1, HGK2, MCK-10, NTRK4, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, TRKE, Tyrosine kinase DDR