GFM2 Antibody

Product Specifications

Background

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

NCBI Gene ID

84340

Swiss Prot

Q969S9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 520-779 of human GFM2 (NP_115756.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

SW480

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 86kDa

Fragment

IgG

Applications Notes

WB: 1:1000 - 1:4000

Symbol

GFM2

Positive Control 2

U-87MG

Positive Control 3

LO2

Positive Control 4

A-431

Positive Control 5

HT-1080

Positive Control 6

K-562

NCBI Official Name

G elongation factor mitochondrial 2

NCBI Organism

Homo sapiens

Other Product Names

EF-G2mt, EFG2, MRRF2, MST027, MSTP027, RRF, RRF2, RRF2mt, hEFG2, mEF-G 2, ribosome-releasing factor 2, mitochondrial, mitochondrial elongation factor G2, mitochondrial ribosome recycling factor 2