CRLF2 Antibody

Product Specifications

Background

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP) . Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

NCBI Gene ID

64109

Swiss Prot

Q9HC73

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines, Immunology, Innate Immunity

Purification

Affinity purification

Positive Control

293T

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 50kDa

Fragment

IgG

Applications Notes

WB: 1:200 - 1:1000

Symbol

CRLF2

Positive Control 2

Jurkat

Positive Control 3

Mouse liver

Positive Control 4

Rat brain

NCBI Official Name

Cytokine receptor like factor 2

NCBI Organism

Homo sapiens

Other Product Names

CRL2Y, TSLPR, CRLF2, cytokine receptor-like factor 2, IL-XR, TSLP receptor, cytokine receptor CRL2 precusor, thymic stromal lymphopoietin protein receptor, thymic stromal-derived lymphopoietin receptor