PADI1 Antibody

Product Specifications

Background

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.

NCBI Gene ID

29943

Swiss Prot

Q9ULC6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PADI1 (NP_037490.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

Affinity purification

Positive Control

A-431

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 65kDa

Fragment

IgG

Applications Notes

WB: 1:200 - 1:1000

Symbol

PADI1

Positive Control 2

SW480

Positive Control 3

U-937

Positive Control 4

HepG2

Positive Control 5

Mouse liver

NCBI Official Name

Peptidyl arginine deiminase 1

NCBI Organism

Homo sapiens

Other Product Names

HPAD1PAD1, PDI, PDI1, protein-arginine deiminase type-1, hPAD-colony 1peptidyl arginine deiminase, type I, peptidylarginine deiminase I, protein-arginine deiminase type I