SMG6 Antibody

Product Specifications

Background

This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.

NCBI Gene ID

23293

Swiss Prot

Q86US8

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1419 of human SMG6 (NP_060045.4) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 210kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

SMG6

Positive Control 2

Jurkat

Positive Control 3

SW620

Positive Control 4

Rat liver

NCBI Official Name

SMG6 nonsense mediated mRNA decay factor

NCBI Organism

Homo sapiens

Other Product Names

C17orf31, EST1A, SMG-6, hSMG5/7a, telomerase-binding protein EST1A, EST1 telomerase component homolog A, ever shorter telomeres 1A, smg-6 homolog, nonsense mediated mRNA decay factor, telomerase subunit EST1A