SCN8A Antibody

Product Specifications

Background

This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

6334

Swiss Prot

Q9UQD0

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1350-1440 of human SCN8A (NP_055006.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity purification

Positive Control

K-562

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 165kDa

Fragment

IgG

Applications Notes

WB: 1:200 - 1:1000

Symbol

SCN8A

Positive Control 2

SH-SY5Y

Positive Control 3

293T

NCBI Official Name

Sodium voltage-gated channel alpha subunit 8

NCBI Organism

Homo sapiens

Other Product Names

BFIS5, CERIII, CIAT, EIEE13, MED, MYOCL2, NaCh6, Nav1.6, PN4, sodium channel protein type 8 subunit alpha, hNa6/Scn8a voltage-gated sodium channel, sodium channel, voltage gated, type VIII, alpha subunit, voltage-gated sodium channel subunit alpha Nav1.6, voltage-gated sodium channel type VIII alpha protein