GAD2 Antibody
Product Specifications
Background
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
NCBI Gene ID
2572
Swiss Prot
Q05329
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 401-585 of human GAD2 (NP_001127838.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Symbol
GAD2
Positive Control 2
U-87MG
NCBI Official Name
Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
NCBI Organism
Homo sapiens
Other Product Names
GAD2, GAD65, glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa), Glutamate decarboxylase-2 (pancreas), 65kD)
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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