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PARP1 Antibody, KO Validated

Product Specifications

Background

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

NCBI Gene ID

142

Swiss Prot

P09874

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Cell Cycle, Immunology, Signal Transduction

Purification

Affinity purification

Positive Control

Jurkat

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=13-327

Calculated Molecular Weight

Observed: 100kDa, 110kDa, 125kDa

Fragment

IgG

Symbol

PARP1

Positive Control 2

HeLa

Positive Control 3

RAW264.7

Positive Control 4

C6

Positive Control 5

Mouse testis

Positive Control 6

Mouse brain

NCBI Official Name

Poly (ADP-ribose) polymerase 1

NCBI Organism

Homo sapiens

Other Product Names

KIF3B, PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1

Tested Applications

WB, IHC, IF, IP, CHIP

Physical Properties

Liquid

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