PARP1 Antibody, KO Validated
Product Specifications
Background
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
NCBI Gene ID
142
Swiss Prot
P09874
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
Jurkat
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 100kDa, 110kDa, 125kDa
Fragment
IgG
Symbol
PARP1
Positive Control 2
HeLa
Positive Control 3
RAW264.7
Positive Control 4
C6
Positive Control 5
Mouse testis
Positive Control 6
Mouse brain
NCBI Official Name
Poly (ADP-ribose) polymerase 1
NCBI Organism
Homo sapiens
Other Product Names
KIF3B, PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1
Tested Applications
WB, IHC, IF, IP, CHIP
Physical Properties
Liquid
Frequently Asked Questions
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