SMARCA4 Antibody, KO Validated

Product Specifications

Background

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

6597

Swiss Prot

P51532

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 30-130 of human SMARCA4 (NP_003063.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Antibody is Knockout validated.

Field of Research

Cancer, Neuroscience, Stem Cell

Purification

Affinity purification

Positive Control

OVCAR3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 180kDa

Fragment

IgG

Symbol

SMARCA4

Positive Control 2

HeLa

NCBI Official Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

NCBI Organism

Homo sapiens

Other Product Names

SMARCA4 Antibody: BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190A, BRG1, SNF2B, Transcription activator BRG1, ATP-dependent helicase SMARCA4