JAK3 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease) .

NCBI Gene ID

3718

Swiss Prot

P52333

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 750-850 of human JAK3 (NP_000206.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Transcription

Purification

Affinity purification

Positive Control

U-87MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 125kDa

Fragment

IgG

Symbol

Jak3

NCBI Official Name

Janus kinase 3

NCBI Organism

Homo sapiens

Other Product Names

JAK-3_HUMAN, JAKL, L-JAK, LJAK, JAK3, tyrosine-protein kinase JAK3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), leukocyte Janus kinase

Tested Applications

WB, IF

Physical Properties

Liquid

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