SOCS3 Antibody

Product Specifications

Background

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

NCBI Gene ID

9021

Swiss Prot

O14543

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human SOCS3 (NP_003946.3) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Obesity, Signal Transduction, Stem Cell

Purification

Affinity purification

Positive Control

Mouse spleen

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 30kDa

Fragment

IgG

Symbol

SOCS3

NCBI Official Name

Suppressor of cytokine signaling 3

NCBI Organism

Homo sapiens

Other Product Names

SOCS3, CIS3, Cish3, SSI-3, SOCS-3, suppressor of cytokine signaling 3, STAT induced STAT inhibitor 3, cytokine-induced SH2 protein 3, SSI3

Tested Applications

WB, IHC, IF

Physical Properties

Liquid

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