IGF1R Antibody

Product Specifications

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

NCBI Gene ID

3480

Swiss Prot

P08069

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 660-760 of human IGF1R (NP_000866.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction

Purification

Affinity purification

Positive Control

293T

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 90kDa/130kDa

Fragment

IgG

Symbol

IGF1R

Positive Control 2

HepG2

Positive Control 3

A375

Positive Control 4

HeLa

Positive Control 5

MCF7

Positive Control 6

Mouse kidney

NCBI Official Name

Insulin-like growth factor 1 receptor

NCBI Organism

Homo sapiens

Other Product Names

IGF1R, CD221 antigen, CD221, IGF1 Receptor, IGFR, IGF-I receptor, Soluble IGF1R variant 1, Soluble IGF1R variant 2, Type 1 IGF receptor, IGFIR, JTK13

Tested Applications

WB, IHC, IF

Physical Properties

Liquid

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