Perforin Antibody
Product Specifications
Background
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
NCBI Gene ID
5551
Swiss Prot
P14222
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin (NP_001076585.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Immunology, Innate Immunity
Purification
Affinity purification
Positive Control
Mouse thymus
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Symbol
PRF1
Positive Control 2
Mouse kidney
NCBI Official Name
Perforin 1 (pore forming protein)
NCBI Organism
Homo sapiens
Other Product Names
PFP, Perforin-1, Cytolysin, P1, PFP, FLH2, PFN1, HPLH2
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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